Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and
molecular glue degraders has arisen as a powerful therapeutic modality for eliminating …

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …

Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Rapid development of bacterial resistance has led to an urgent need to find new druggable
targets for antibiotics. In this context, residue‐specific chemoproteomic approaches enable …

The reactivities of cyclic enones and α, β-unsaturated lactones were characterized by
following the kinetics of their reactions with colored carbon-centered reference nucleophiles …

Lymphoid malignancies are a group of highly heterogeneous diseases frequently
associated with constitutive activation of the nuclear factor kappa B (NF-κB) signaling …

It has been well-established that the deubiquitinating enzyme ubiquitin-specific peptidase 7
(USP7) supports cancer growth by up-regulating multiple cellular pathways, including Wnt/β …

ABSTRACT Introduction Sesquiterpene lactones (SLs) are one of the most diverse bioactive
secondary metabolites found in plants and exhibit a broad range of therapeutic properties …