Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

The cyclic GMP‒AMP synthase (cGAS)‒stimulator of interferon genes (STING) signaling
pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling …

Reactive oxygen species (ROS) scavenging therapy toward acute kidney injury (AKI) is
promising, but no effective ROS scavenging drug has been developed yet. Moreover, cell …

The pathogenesis of acute kidney injury (AKI) is still not fully understood, and effective
interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was …

Renal fibrosis is a typical pathological change in chronic kidney disease (CKD). Epithelial-
mesenchymal transition (EMT) is the predominant stage. Activation of macroautophagy …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

Early diagnosis of chronic kidney disease (CKD) and constant monitoring to guide optimal
intervention is critical to prevent renal failure and other critical diseases. However, the …

Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various
solid cancers. However, its clinical effectiveness is strongly limited by frequent severe …

Background: Activated fibroblasts are present in the injury response, tumorigenesis, fibrosis,
and inflammation in a variety of tissues and myriad disease types. Summary: During normal …

Ischemia/reperfusion (IR) injury contributes to disability and mortality worldwide. Due to the
complicated mechanisms and lack of proper therapeutic targets, few interventions are …