Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

A wide variety of bacterial pathogens secrete a unique class of proteins that attack target cell
membranes and form transmembrane oligomeric pores with distinct β-barrel structural …

Vibrio α-hemolysins (αHLs) are β-pore-forming toxins secreted by Vibrio pathogens, crucial
for the facilitation of bacterial infections through host cell lysis. These toxins are produced as …

Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). Upon encountering
the target cells, VCC forms heptameric β-barrel pores and permeabilizes the cell …

Vibrio cholerae cytolysin (VCC) is a membrane‐damaging protein toxin with potent
cytolytic/cytotoxic activity against wide range of eukaryotic cells. VCC is a β‐barrel pore …

This study describes, to some extent, the VCC contribution as an early stimulation of the
macrophage lineage. Regarding the onset of the innate immune response caused by …

V ibrio cholerae cytolysin (VCC) permeabilizes target cell membranes by forming
transmembrane oligomeric β‐barrel pores. VCC has been shown to associate with the target …

Vibrio cholerae cytolysin (VCC) is a β‐barrel pore‐forming toxin (β‐PFT). It exhibits potent
hemolytic activity against erythrocytes that appears to be a direct outcome of its pore …

Pore-forming toxins (PFTs) are a distinct class of membrane-damaging cytolytic proteins that
contribute significantly towards the virulence processes employed by various pathogenic …

Animal venoms are a complex mixture of highly specialized toxic molecules. Among them,
pore-forming proteins (PFPs) or toxins (PFTs) are one of the major disease-causing toxic …