Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

I Vanmeerbeek, J Sprooten, D De Ruysscher… - …, 2020 - Taylor & Francis
The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …

The role of natural killer T cells in cancer—a phenotypical and functional approach

D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone

S Zhou, Q Shang, N Wang, Q Li, A Song… - Journal of Controlled …, 2020 - Elsevier
Chemotherapy sometimes can cause potential tumor-specific T-cell-mediated immune
response via stimulating immunogenic cell death (ICD). However, such immune response is …

Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy

J Zhang, J Yang, T Zuo, S Ma, N Xokrat, Z Hu, Z Wang… - Biomaterials, 2021 - Elsevier
The normal chemotherapy only induces the intracellular apoptosis pathway to promote
primary tumor cells death, while not inhibit tumor metastasis. Herein, we proposed a kind of …

The current landscape of NKT cell immunotherapy and the hills ahead

A Nelson, JD Lukacs, B Johnston - Cancers, 2021 - mdpi.com
Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …

[HTML][HTML] Co-delivery of gemcitabine and paclitaxel plus NanoCpG empowers chemoimmunotherapy of postoperative “cold” triple-negative breast cancer

B Guo, Y Qu, Y Sun, S Zhao, J Yuan, P Zhang… - Bioactive materials, 2023 - Elsevier
Triple-negative breast cancer (TNBC) due to lack of clear target and notorious “cold” tumor
microenvironment (TME) is one of the most intractable and lethal malignancies. Tuning …

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

C Song, H Phuengkham, YS Kim, VV Dinh, I Lee… - Nature …, 2019 - nature.com
The low response rate of current cancer immunotherapy suggests the presence of few
antigen-specific T cells and a high number of immunosuppressive factors in tumor …

CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

K Hadiloo, S Tahmasebi, A Esmaeilzadeh - Cancer Cell International, 2023 - Springer
Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Recent advancements in nanomedicine for 'cold'tumor immunotherapy

Q Chen, T Sun, C Jiang - Nano-micro letters, 2021 - Springer
Although current anticancer immunotherapies using immune checkpoint inhibitors (ICIs)
have been reported with a high clinical success rate, numerous patients still bear …

[HTML][HTML] Immunogenic cell death inducer peptides: A new approach for cancer therapy, current status and future perspectives

H Aria, M Rezaei - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Immunogenic Cell Death (ICD) is a type of cell death that kills tumor cells by
stimulating the adaptive immune response against other tumor cells. ICD depends on the …