The ongoing pandemic illustrates limited therapeutic options for controlling SARS-CoV-2
infections, calling a need for additional therapeutic targets. The viral spike S glycoprotein …

COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in
the history of mankind, and has already infected a huge population across the globe. This …

Since the first description of COVID-19 infection, among clinical manifestations of the
disease, including fever, dyspnea, cough, and fatigue, it was observed a high incidence of …

The multi-dimensional challenge of drug resistance is one of the pivotal hindrances for
cancer chemotherapy. A reductive approach to define and distinguish the main aspects of …

In general, an individual who experiences the symptoms of Severe Acute Respiratory
Syndrome Coronavirus 2 or SARS-CoV-2 infection is declared as recovered after 2 weeks …

COVID-19 is a progressing pandemic of coronavirus disease-2019, which had drowned the
whole world in a deep sorrow sea. Uncountable deaths were extending the list of deaths …

The SARS-CoV-2 main protease (Mpro) is a crucial enzyme for viral replication and has
been considered an attractive drug target for the treatment of COVID-19. In this study, virtual …

Serine proteases (SP), including furin, trypsin, and TMPRSS2 cleave the SARS-CoV-2 spike
(S) protein, enabling the virus to enter cells. Here, we show that factor (F) Xa, an SP involved …

Abstract The coronavirus disease‐19 (COVID‐19) pandemic has become a global threat
since its first outbreak at the end of 2019. Several review articles have been published …

Activated protein C (APC), thrombin, and factor (f) Xa are vitamin K-dependent serine
proteases that are key factors in blood coagulation. Moreover, they play important roles in …