The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the
urgent need to refocus on the question of which T-cell responses are required to control HIV …

Major histocompatibility complex (MHC) gene products control the repertoire of T cell
responses that an individual may create against pathogens and foreign tissues. This text will …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

We previously demonstrated that HIV replication is concentrated in lymph node B cell
follicles during chronic infection and that HIV-specific CTL fail to accumulate in large …

An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To
address this issue in macaques, we administered a live-attenuated simian …

The human immunodeficiency virus (HIV) infection of the immune cells expressing the
cluster of differentiation 4 cell surface glycoprotein (CD4+ cells) causes progressive decline …

The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA
class I alleles suggests that some CD8+ T-cell responses may be more effective than others …

Developing biological interventions to control human immunodeficiency virus (HIV)
replication in the absence of antiretroviral therapy (ART) could contribute to the development …

Abstract HLA-B27-and-B57-positive HIV-infected humans have long been associated with
control of HIV replication, implying that CD8+ T cell responses contribute to control of viral …

The complex interplay between the host immune response and HIV has been the subject of
intense research over the last 25 years. HIV and simian immunodeficiency virus (SIV) CD8+ …