Epigenetic regulation and cancer

QW Chen, XY Zhu, YY Li, ZQ Meng - Oncology reports, 2014 - spandidos-publications.com
Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation …

I Muller, AR Jex, SHI Kappe, SA Mikolajczak… - International journal for …, 2019 - Elsevier
Plasmodium vivax is the key obstacle to malaria elimination in Asia and Latin America,
largely attributed to its ability to form resilient hypnozoites (sleeper cells) in the host liver that …

[HTML][HTML] Epigenome-wide association study of leukocyte telomere length

Y Lee, D Sun, APS Ori, AT Lu, A Seeboth… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Telomere length is associated with age-related diseases and is highly heritable. It is unclear,
however, to what extent epigenetic modifications are associated with leukocyte telomere …

YPEL3 suppresses epithelial–mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway

J Zhang, X Wen, XY Ren, YQ Li, XR Tang… - Journal of experimental …, 2016 - Springer
Background Metastasis remains the major cause of death in nasopharyngeal carcinoma
(NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function …

YPEL3 expression induces cellular senescence via the Hippo signaling pathway in human breast cancer cells

Y Kwon, H Lee, H Park, B Lee, TU Kwon, YJ Kwon… - Toxicological …, 2023 - Springer
The Hippo pathway is a signaling pathway that controls organ size in animals by regulating
cell proliferation and apoptosis. Yes-associated protein 1 (YAP1), an oncogene associated …

[HTML][HTML] Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance

G Turan, ÇE Olgun, H Ayten, P Toker… - Protein Science: a …, 2024 - ncbi.nlm.nih.gov
YPEL2 is a member of the evolutionarily conserved YPEL family involved in cellular
proliferation, mobility, differentiation, senescence, and death. However, the mechanism by …

Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen‐induced cellular senescence

R Tuttle, KR Miller, JN Maiorano… - … journal of cancer, 2012 - Wiley Online Library
Estrogen signaling plays an important role in breast carcinogenesis. An increased
understanding of estrogen gene targets and their effects will allow for more directed and …

The protein p17 signaling pathways in cancer

K Heese - Tumor Biology, 2013 - Springer
P17 is a novel neuronal protein expressed under physiological conditions only at very low
levels in other tissues. Accumulating data indicate its crucial involvement in tumorigenic …

Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes

HS Baek, TU Kwon, S Shin, YJ Kwon, YJ Chun - Scientific Reports, 2021 - nature.com
Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of
dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate …

Comprehensive analysis of the expression and prognosis of YPEL family members in clear cell renal cell cancer

L Wang, Z Zhang, X Zhou, J Wu… - Oncology …, 2022 - spandidos-publications.com
The Yippee‑like (YPEL) gene family is composed of five members encoding a protein
containing a zinc finger‑like metal‑binding domain. Due to its structure and location in cells …