Oxidative stress and inflammation are associated with skeletal muscle function decline with
ageing or disease or inadequate exercise and/or poor diet. Paradoxically, reactive oxygen …

Idiopathic inflammatory myopathies (IIMs) are common autoimmune diseases that affect
skeletal muscle quality and function. The lack of an early diagnosis and treatment can lead …

Metabarcoding is a powerful molecular tool for simultaneously surveying hundreds to
thousands of species from a single sample, underpinning microbiome and environmental …

Biomolecular control enables leveraging cells as biomanufacturing factories. Despite recent
advancements, we currently lack genetically encoded modules that can be deployed to …

Gene expression inherently gives rise to stochastic variation (“noise”) in the production of
gene products. Minimizing noise is crucial for ensuring reliable cellular functions. However …

Triggering of cellular events often relies on the level of a key gene product crossing a critical
threshold. Achieving precision in event timing despite noisy gene expression facilitates high …

Multistable switches are ubiquitous building blocks in both systems and synthetic biology.
Given their central role, it is thus imperative to understand how their fundamental properties …

Small regulatory RNA molecules such as microRNA modulate gene expression through
inhibiting the translation of messenger RNA (mRNA). Such posttranscriptional regulation …

While the vision of synthetic biology is to create complex genetic systems in a rational
fashion, system-level behaviors are often perplexing due to the context-dependent dynamics …

Triggering of cellular events often relies on the level of a key gene product crossing a critical
threshold. Achieving precision in event timing in spite of noisy gene expression facilitates …