The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

Brucella is a facultative intracellular pathogen that causes zoonotic infection known as
brucellosis which results in abortion and infertility in natural host. Humans, especially in low …

The merits of exercise on muscle health and well-being are numerous and well
documented. However, the mechanisms underlying the robust adaptations induced by …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative diseases
that are characterized by axonopathy of the corticospinal motor neurons. A mutation in the …

Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated
membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by …

In response to nutrient deprivation, the cell mobilizes an extensive amount of membrane to
form and grow the autophagosome, allowing the progression of autophagy. By providing …

Bacteria of the genus B rucella are intracellular vacuolar pathogens of mammals that cause
the worldwide zoonosis brucellosis, and reside within phagocytes of infected hosts to …

Recent work supports the idea that cisternae of the Golgi apparatus can be assigned to
three classes, which correspond to discrete stages of cisternal maturation. Each stage has a …

The export of newly synthesized proteins from the endoplasmic reticulum is fundamental to
the ongoing maintenance of cell and tissue structure and function. After co-translational …