Genomics, convergent neuroscience and progress in understanding autism spectrum disorder

HR Willsey, AJ Willsey, B Wang… - Nature Reviews …, 2022 - nature.com
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

[HTML][HTML] The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Association of psychiatric disorders with mortality among patients with COVID-19

K Nemani, C Li, M Olfson, EM Blessing… - JAMA …, 2021 - jamanetwork.com
Importance To date, the association of psychiatric diagnoses with mortality in patients
infected with coronavirus disease 2019 (COVID-19) has not been evaluated. Objective To …

Schizophrenia risk from complex variation of complement component 4

A Sekar, AR Bialas, H De Rivera, A Davis… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia's strongest genetic association at a population level involves variation in the …

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Z Li, J Chen, H Yu, L He, Y Xu, D Zhang, Q Yi, C Li… - Nature …, 2017 - nature.com
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Biological insights from 108 schizophrenia-associated genetic loci

C Pantelis, GN Papadimitriou, S Papiol… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

A Ganna, KJH Verweij, MG Nivard, R Maier, R Wedow… - Science, 2019 - science.org
INTRODUCTION Across human societies and in both sexes, some 2 to 10% of individuals
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …

[HTML][HTML] Biological insights from 108 schizophrenia-associated genetic loci

S Ripke, BM Neale, A Corvin, JTR Walters, KH Farh… - Nature, 2014 - ncbi.nlm.nih.gov
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

[HTML][HTML] Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

CE Murphy, AK Walker, CS Weickert - Translational psychiatry, 2021 - nature.com
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Genetics of Parkinson's disease

CM Lill - Molecular and cellular probes, 2016 - Elsevier
Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …