Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

Cellular activity in the brain depends on the high energetic support provided by
mitochondria, the cell organelles which use energy sources to generate ATP,,,. Acute …

The ability of microglia to acquire diverse states of activation, or phenotypes, reflects
different features that are determinant for their contribution to homeostasis in the adult CNS …

Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …

Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …

Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression
levels and receptor occupancy by small molecules are highly desirable. We report the …

Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the
treatment of numerous conditions, including inflammatory diseases, autoimmune disorders …

The human endocannabinoid system (ECS) is a complex signalling network involved in
many key physiological processes. The ECS includes the cannabinoid receptors, the …

Cannabinoid type 2 receptor (CB2R) is an attractive target for the treatment of pain and
inflammatory disorders. Availability of a selective CB2R fluorescent ligand to study CB2R …