The emerging role of epigenetic therapeutics in immuno-oncology
MJ Topper, M Vaz, KA Marrone, JR Brahmer… - Nature Reviews …, 2020 - nature.com
The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
Antigen presentation in cancer—mechanisms and clinical implications for immunotherapy
Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …
clinical management of many types of cancers. However, long-term durable tumour control …
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution
C Puttick, TP Jones, MM Leung, F Galvez-Cancino… - Nature Genetics, 2024 - nature.com
Disruption of the class I human leukocyte antigen (HLA) molecules has important
implications for immune evasion and tumor evolution. We developed major …
implications for immune evasion and tumor evolution. We developed major …
[HTML][HTML] Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape
Cancer immunotherapy is now established as a powerful way to treat cancer. The recent
clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) …
clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) …
[HTML][HTML] Deregulation of HLA-I in cancer and its central importance for immunotherapy
It is now well accepted that many tumors undergo a process of clonal selection which means
that tumor antigens arising at various stages of tumor progression are likely to be …
that tumor antigens arising at various stages of tumor progression are likely to be …
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
Monalizumab: inhibiting the novel immune checkpoint NKG2A
T Van Hall, P André, A Horowitz, DF Ruan… - … for immunotherapy of …, 2019 - Springer
The implementation of immune checkpoint inhibitors to the oncology clinic signified a new
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
era in cancer treatment. After the first indication of melanoma, an increasing list of additional …
HLA-A* 03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study
Background Predictive biomarkers could allow more precise use of immune checkpoint
inhibitors (ICIs) in treating advanced cancers. Given the central role of HLA molecules in …
inhibitors (ICIs) in treating advanced cancers. Given the central role of HLA molecules in …
HIV-1 and human genetic variation
PJ McLaren, J Fellay - Nature Reviews Genetics, 2021 - nature.com
Over the past four decades, research on the natural history of HIV infection has described
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
how HIV wreaks havoc on human immunity and causes AIDS. HIV host genomic research …
A genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …