The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Neural mechanisms of aggression across species

JE Lischinsky, D Lin - Nature neuroscience, 2020 - nature.com
Aggression is a social behavior essential for securing resources and defending oneself and
family. Thanks to its indispensable function in competition and thus survival, aggression …

[HTML][HTML] Cellular anatomy of the mouse primary motor cortex

R Muñoz-Castañeda, B Zingg, KS Matho, X Chen… - Nature, 2021 - nature.com
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

Oestrogen engages brain MC4R signalling to drive physical activity in female mice

WC Krause, R Rodriguez, B Gegenhuber, N Matharu… - Nature, 2021 - nature.com
Oestrogen depletion in rodents and humans leads to inactivity, fat accumulation and
diabetes,, underscoring the conserved metabolic benefits of oestrogen that inevitably …

The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

[HTML][HTML] Multimodal analysis of cell types in a hypothalamic node controlling social behavior

DW Kim, Z Yao, LT Graybuck, TK Kim, TN Nguyen… - Cell, 2019 - cell.com
The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains∼ 4,000
neurons that project to multiple targets and control innate social behaviors including …

Top-down regulation of motivated behaviors via lateral septum sub-circuits

A Besnard, F Leroy - Molecular psychiatry, 2022 - nature.com
How does cognition regulate innate behaviors? While the cognitive functions of the cortex
have been extensively studied, we know much less about how cognition can regulate innate …

Distinct hypothalamic control of same-and opposite-sex mounting behaviour in mice

T Karigo, A Kennedy, B Yang, M Liu, D Tai, IA Wahle… - Nature, 2021 - nature.com
Animal behaviours that are superficially similar can express different intents in different
contexts, but how this flexibility is achieved at the level of neural circuits is not understood …

An approximate line attractor in the hypothalamus encodes an aggressive state

A Nair, T Karigo, B Yang, S Ganguli, MJ Schnitzer… - Cell, 2023 - cell.com
The hypothalamus regulates innate social behaviors, including mating and aggression.
These behaviors can be evoked by optogenetic stimulation of specific neuronal …

Autism spectrum disorder genetics and the search for pathological mechanisms

DS Manoli, MW State - American Journal of Psychiatry, 2021 - Am Psychiatric Assoc
Recent progress in the identification of genes and genomic regions contributing to autism
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …