Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

A hypertensive emergency is a situation in which uncontrolled hypertension is associated
with acute end-organ damage. Most patients presenting with hypertensive emergency have …

The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

Recent evidence suggesting a strong interplay between components of the renin–
angiotensin system and key mediators of fibrosis led us to hypothesize that renin …

Angiotensin (Ang) II is not only generated in the circulation by renin and angiotensin-
converting enzyme (ACE) but also is produced locally in numerous organs including kidney …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …

With the development of aliskiren, blockade of the renin–angiotensin–aldosterone system
(RAAS) at the level of the interaction of renin with a substrate has become a clinical reality …

We compared the effect n-3 polyunsaturated fatty acids (PUFAs) with direct renin inhibition
on electrophysiological remodeling in angiotensin II–induced cardiac injury. We treated …

A reaction between enzyme renin and its only natural substrate angiotensinogen is the initial
and rate-limiting step for producing a potent vasoconstrictor angiotensin II as the final …

The first evidence of the existence of renin was presented over 100 years ago. However, the
importance of renin and the renin–angiotensin system in the pathogenesis of cardiovascular …