Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Impaired cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI)
is known to be associated with worse global outcome at 6–12 months. As technology has …

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding
cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator …

Abstract ATP-sensitive potassium (K ATP) channels are ubiquitously expressed on the
plasma membrane of cells in multiple organs, including the heart, pancreas and brain. K …

Cerebral edema and contusion expansion are major determinants of morbidity and mortality
after TBI. Current treatment options are reactive, suboptimal and associated with significant …

Objectives: Intracranial pressure in traumatic brain injury is dynamic and influenced by
factors like injury patterns, treatments, and genetics. Existing studies use time invariant …

Current approaches have failed to yield success in the translation of neuroprotective
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …

Introduction Cerebral edema is a key contributor to death and disability in several forms of
brain injury. Current treatment options are limited, reactive, and associated with significant …

In severe traumatic brain injury (TBI), contusions often are worsened by contusion
expansion or hemorrhagic progression of contusion (HPC), which may double the original …

There is a growing literature on the impact of genetic variation on outcome in traumatic brain
injury (TBI). Whereas a substantial proportion of these publications have focused on the …