The idea that resources are limited and animals can maximise fitness by trading costly
activities off against one another forms the basis of life-history theory. Although investment in …

The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …

Research programmes on oxidative stress and hormesis are wide ranging. Biomedical and
toxicological sciences have traditionally centralised such research, but in the last years we …

Life‐history theory concerns the trade‐offs that mold the patterns of investment by animals
between reproduction, growth, and survival. It is widely recognized that physiology plays a …

Telomeres are highly conserved regions of DNA that protect the ends of linear
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …

Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived
rodent, has increased proteasome activity and lower levels of protein ubiquitination …

Birds naturally have blood glucose concentrations that are nearly double levels measured
for mammals of similar body size and studies have shown that birds are resistant to insulin …

The mechanisms that underpin the evolution of ageing and life histories remain elusive.
Oxidative stress, which results in accumulated cellular damages, is one of the mechanisms …

With few exceptions, nutritional and dietary interventions generally impact upon both old-
age quality of life and longevity. The life prolonging effects, commonly observed with dietary …

Birds (Aves) display high metabolic rates and oxygen consumption relative to mammals,
increasing reactive oxygen species (ROS) formation. Although excess ROS reduces lifespan …