Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

Discovered as organometallic curiosities in the 1970s, carbene radicals have become a
staple in modern-day homogeneous catalysis. Carbene radicals exhibit nucleophilic radical …

Indolines are ubiquitous structural motifs occurring in pharmaceuticals and natural products.
Here, we report a strategy for regio-and stereoselective C (sp 3)–H functionalization of N …

In view of the importance and beneficial characteristics of enantioenriched tertiary alcohols
in pharmaceutical chemistry, efficient and green strategies for their synthesis are highly …

A diverse array of natural products has been produced by cell biofactories through metabolic
engineering, in which enzymes play essential roles in the complex metabolic network …

Design of metal cofactor ligands is essential for controlling the reactivity of metalloenzymes.
We investigated a carbene transfer reaction catalyzed by myoglobins containing iron …

In this study, we developed a machine-learning-aided protein design strategy for
engineering Vitreoscilla hemoglobin (VHb) as carbene transferase. A Natural Language …

Protein engineering of cytochrome P450s has enabled these biocatalysts to promote a
variety of abiotic reactions beyond nature's repertoire. Integrating such non‐natural …

Rieske oxygenases (ROs) are a diverse metalloenzyme class with growing potential in
bioconversion and synthetic applications. We postulated that ROs are nonetheless …

Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone
for the efficient creation of enantiopure chiral molecules characterized by their high …