CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Neutrophils are frontline cells of the innate immune system. These effector leukocytes are
equipped with intriguing antimicrobial machinery and consequently display high cytotoxic …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …

Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …

Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress
anti-tumor immune response and promote tumor growth. Chemokines play a vital role in …

Colorectal cancer (CRC) is among the top 3 leading causes of cancer-related deaths, and
tumor malignant progression and metastases contribute to the high mortality of advanced …

Colorectal cancer (CRC) is one of the most common cancer types and represents a major
therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well …

Purpose: Tumor infiltration by different T lymphocyte subsets is known to be associated with
favorable prognosis in colorectal cancer. Still debated is the role of innate immune system …

Objective Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively
participates in tumour progression. The anterior gradient-2 (AGR2) can be secreted to …