Triple negative breast cancer treatment options and limitations: future outlook

O Obidiro, G Battogtokh, EO Akala - Pharmaceutics, 2023 - mdpi.com
Triple negative breast cancer (TNBC) has a negative expression of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor receptors (HER2). The …

Treatment strategies against triple-negative breast cancer: an updated review

M Maqbool, F Bekele, G Fekadu - Breast Cancer: Targets and …, 2023 - Taylor & Francis
Triple-negative breast cancer (TNBC) is associated with an increased risk of early
recurrence and distant metastasis, as well as the development of therapeutic resistance and …

Dual roles of metal–organic frameworks as nanocarriers for miRNA delivery and adjuvants for chemodynamic therapy

H Zhao, T Li, C Yao, Z Gu, C Liu, J Li… - ACS Applied Materials & …, 2021 - ACS Publications
MicroRNA (miRNA) represents a promising class of therapeutic nucleic acid drugs, while
delivery challenges remain that impede the advancement of miRNA therapy, largely …

Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

P Li, Q Lin, S Sun, N Yang, Y Xia, S Cao… - Cell Death & …, 2022 - nature.com
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that
displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for …

Anticancer activity of palladium-based complexes against triple-negative breast cancer

M Vojtek, MPM Marques, IM Ferreira, H Mota-Filipe… - Drug Discovery …, 2019 - Elsevier
Highlights•TNBC is an unmet medical need with poor survival rates and no targeted
therapy.•TNBC resists conventional chemotherapy and surgical strategies.•A review of 121 …

The Antitriple Negative Breast cancer Efficacy of Spatholobus suberectus Dunn on ROS‐Induced Noncanonical Inflammasome Pyroptotic Pathway

F Zhang, Q Liu, K Ganesan, Z Kewu… - Oxidative Medicine …, 2021 - Wiley Online Library
Breast cancer (BCa) is the leading cause of women's death worldwide; among them, triple‐
negative breast cancer (TNBC) is one of the most troublesome subtypes with easy …

Evaluating the influence of Human Umbilical Cord Mesenchymal Stem Cells-derived exosomes loaded with miR-3182 on metastatic performance of Triple Negative …

Y Khazaei-Poul, S Shojaei, A Koochaki, H Ghanbarian… - Life sciences, 2021 - Elsevier
Abstract Aims Deregulation of microRNA (miRNA) function has been linked to numerous
human cancers, such as Triple Negative Breast Cancer (TNBC). Exosomes, a subgroup of …

[HTML][HTML] Histologic heterogeneity of triple negative breast cancer: A National Cancer Centre Database analysis

MN Mills, GQ Yang, DE Oliver, CL Liveringhouse… - European journal of …, 2018 - Elsevier
Background Triple negative breast cancer (TNBC) is an aggressive disease, but recent
studies have identified heterogeneity in patient outcomes. However, the utility of histologic …

BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype–phenotype correlation in a cohort of 531 patients

L Incorvaia, D Fanale, M Bono, V Calò… - Therapeutic …, 2020 - journals.sagepub.com
Background: Several available data suggest the association between specific molecular
subtypes and BRCA1/2 mutational status. Previous investigations showed the association …

[HTML][HTML] Nanosoldiers: A promising strategy to combat triple negative breast cancer

A Pawar, P Prabhu - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstracts The phenomenal rise in cancer over the past few years has made it the second
leading cause of death worldwide. Breast cancer constitutes the predominant cancer …