Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

Injectable hydrogels with pH-responsiveness and self-healing ability have great potential for
anti-cancer drug delivery. Herein, we developed a series of polysaccharide-based self …

Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Efficient cellular delivery of biologically active molecules is one of the key factors that affect
the discovery and development of novel drugs. The plasma membrane is the first barrier that …

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug
delivery carriers for their ability to improve on drug tolerability, circulation half-life, and …

In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

1.1. General Strategies in the Design of Tumor Targeted Therapeutics. Today's quest for
developing tumor-targeted therapies has naturally followed two nonoverlapping strategies …

Cancer therapies that exploit targeting ligands to deliver attached cytotoxic drugs selectively
to malignant cells are currently receiving significant attention. While antibody-targeted drugs …