A deeper understanding of the pathomechanisms leading to stress-related psychiatric
disorders is important for the development of more efficient preventive and therapeutic …

Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

One of the most exciting discoveries in the learning and memory field in the past two
decades is the observation that active regulation of gene expression is necessary for …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD …

Past analyses examining the relationship between genetic variation in the 5, 10-
methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have …

Memory impairment is the main feature of Alzheimer's disease (AD). Initial impairments
originate in the temporal lobe area and propagate throughout the brain in a sequential …

Psychiatric diseases are multifaceted disorders with complex etiology, recognized to have
strong heritable components. Despite intense research efforts, genetic loci that substantially …

Progranulin (GRN) haploinsufficiency is a frequent cause of familial frontotemporal
dementia, a currently untreatable progressive neurodegenerative disease. By chemical …

Exposure to trauma is one of the most important and prevalent risk factors for mental and
physical ill-health. Excessive or prolonged stress exposure increases the risk of a wide …