Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

MR1 ESGE recommends the following standards for Barrett esophagus (BE) surveillance:–a
minimum of 1-minute inspection time per cm of BE length during a surveillance endoscopy …

While the genomes of normal tissues undergo dynamic changes over time, little is
understood about the temporal-spatial dynamics of genomes in premalignant tissues that …

Cancer development is a dynamic evolutionary process characterized by marked
intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett …

Background & Aims Dysplasia in Barrett's esophagus often is invisible on high-resolution
white-light endoscopy (HRWLE). We compared the diagnostic accuracy for inconspicuous …

Background & Aims The aim of this study was to characterize baseline morphologic features
of crypts in nondysplastic Barrett's esophagus and correlate them with DNA content …

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …

Background and Aims Current understanding of the risk of neoplastic progression in patients
with Barrett's esophagus with indefinite dysplasia (BE-IND) stems from small retrospective …

Aims Barrett's oesophagus with indefinite for dysplasia (BE‐IND) is a subjective diagnosis
with a low interobserver agreement (IOA) among pathologists and uncertain clinical …