Caulobacter crescentus is widely used as a powerful model system for the study of
prokaryotic cell biology and development. Analysis of this organism is complicated by a …

The chromosomal origin and terminus of replication are precisely localized in bacterial cells.
We examined the cellular position of 112 individual loci that are dispersed over the circular …

To further explore possible avenues for accessing microbial biodiversity for drug discovery
from natural products, we constructed and screened a 5,000-clone “shotgun” environmental …

Faithful chromosome segregation is an essential component of cell division in all organisms.
The eukaryotic mitotic machinery uses the cytoskeleton to move specific chromosomal …

Maytansinoids are potent antitumor agents found in plants and microorganisms. To
elucidate their biosynthesis at the biochemical and genetic level and to set the stage for their …

Streptomycetes grow by cell wall extension at hyphal tips. The molecular basis for such
polar growth in prokaryotes is largely unknown. It is reported here that DivIVASC, the …

The ability of Ralstonia solanacearum strain GMI1000 to cause disease on a wide range of
host plants (including most Solanaceae and Arabidopsis thaliana) depends on genes …

Micrococcus luteus secretes a small protein called Rpf, which has autocrine and paracrine
signalling functions and is required for the resuscitation of dormant cells. Originally isolated …

Acinetobacter sp. strain ADP1 is a naturally transformable gram-negative bacterium with
simple culture requirements, a prototrophic metabolism and a compact genome of 3.7 Mb …

Expression of the Pseudomonas aeruginosa type III secretion system is induced by contact
with eukaryotic cells, serum or low Ca2+ concentrations. We report that ExsD, a unique …