Imbalances between excitation and inhibition in synaptic transmission and neural circuits
have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are …

Neurodevelopmental disorders such as fragile X syndrome (FXS) result in lifelong cognitive
and behavioural deficits and represent a major public health burden. FXS is the most …

Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

The Ras-MAPK and PI3K-AKT-mTOR signaling cascades were originally identified as
cancer regulatory pathways but have now been demonstrated to be critical for synaptic …

BACKGROUND FXLEARN, the first-ever large multisite trial of effects of disease-targeted
pharmacotherapy on learning, was designed to explore a paradigm for measuring effects of …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Fragile X syndrome (FXS), an inherited intellectual disability often associated with autism, is
caused by the loss of expression of the fragile X mental retardation protein. Tremendous …

Converging lines of evidence support the use of environmental stimulation to ameliorate the
symptoms of a variety of neurodevelopmental disorders. Applying these interventions at very …

Previous studies have hypothesized that diverse genetic causes of intellectual disability (ID)
and autism spectrum disorders (ASDs) converge on common cellular pathways. Testing this …