Comprehensive study of the major chromosomal/molecular abnormalities in children and
adults with acute lymphoblastic leukemia (ALL) has demonstrated prognostic utility for many …

A new member of the Bcl-2 family was identified, Bcl-G. The human BCL-G gene consists of
6 exons, resides on chromosome 12p12, and encodes two proteins through alternative …

Approximately 20% of childhood B-precursor acute lymphoblastic leukemia (ALL) has a TEL-
AML1 fusion gene, often in association with deletions of the nonrearranged TEL allele. TEL …

The strength and duration of B-cell–receptor (BCR) signaling depends upon the balance
between protein tyrosine kinase (PTK) activation and protein tyrosine phosphatase (PTP) …

The occurrence of childhood acute lymphoblastic leukemia (ALL) in 2 of 3 triplets provided a
unique opportunity for the investigation of leukemogenesis and the natural history of ALL …

The TEL-AML1 fusion which results from the t (12; 21) rearrangement in childhood B-precur-
sor acute lymphoblastic leukaemia (B-precursor ALL) is often accompanied by loss of the …

Allelic losses on chromosome 12p12-13 are associated with childhood acute lymphoblastic
leukemia (ALL) and several solid neoplasias, suggesting the presence of a tumor …

Loss of heterozygosity of the short arm of chromosome 12 is a frequent event in a wide
range of haematological malignancies and solid tumours. In previous studies, the shortest …

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune
system from luminal microorganisms, thereby contributing directly to the regulation of …

BACKGROUND AND OBJECTIVES: The TEL/AML1 fusion is the most common genetic
abnormality found in childhood acute lymphoblastic leukemias (ALL). Although it is very …