Antibodies to mammalian dsDNA have, for decades, been linked to systemic lupus
erythematosus (SLE) and particularly to its most serious complication, lupus nephritis. This …

The inclusion of'the anti-DNA antibody'by the ACR and the Systemic Lupus International
Collaborating Clinics (SLICC) as a criterion for systemic lupus erythematosus does not …

Systemic lupus erythematosus (SLE) is an autoimmune syndrome characterized by
autoantibodies to nuclear constituents. Some of these antibodies are diagnostically …

One cannot discuss anti-dsDNA antibodies and lupus nephritis without discussing the
nature of Systemic lupus erythematosus (SLE). SLE is insistently described as a prototype …

Systemic lupus erythematosus is an inflammatory autoimmune syndrome of unknown cause.
Kidney disease is a central and serious complication in this syndrome. Deposition of …

Autoantibodies are key mediators in determining the clinical manifestations of systemic
lupus erythematosus (SLE). The mechanisms by which antibodies may be harmful to self …

Antibodies that are directed against components of the cell nucleus almost always
accompany systemic lupus erythematosus (SLE). Formation of antibodies against double …

Nucleosomes play a central role in the antinuclear antibody response in lupus. Lupus anti-
dsDNA and antihistone antibodies directed toward nucleosomes belong together with …

Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology.
The major hallmark of this disease is the presence of antibodies against nuclear …

Mechanisms for the generation of anti-dsDNA autoantibodies are still not completely
elucidated. One theory states that dsDNA interacts for mimicry with antibodies raised versus …