Up to 1.5 billion people worldwide suffer from various forms of hearing loss, with an
additional 1.1 billion people at risk from various insults such as increased consumption of …

Inherited forms of blindness and deafness are highly prevalent and severe conditions that
significantly impact the lives of millions of people worldwide. The lack of therapeutic options …

Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15
(PCDH15) gene, is characterized by congenital lack of hearing and balance, and …

A prevalent recessive mutation (c. 2485C> T, p. Q829X) within the OTOF gene leads to
profound prelingual hearing loss. Here we show that in Otof mice harbouring a mutation (c …

Deaminases, ubiquitous enzymes found in all living organisms from bacteria to humans,
serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while …

Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15
(PCDH15) gene, is characterized by congenital lack of hearing and balance, and …

Substantial efforts have been made for local administration of small molecules or biologics
in treating hearing loss diseases caused by either trauma, genetic mutations, or drug …

Pathogenic structure variations (SVs) are associated with various types of cancer and rare
genetic diseases. Recent studies have used Cas9 nuclease with paired guide RNAs …

Auditory neuropathy (AN) is an under-recognized form of hearing loss characterized by
lesions in inner hair cells (IHCs), ribbon synapses and spiral ganglion neurons (SGNs). The …

Lowe syndrome, a rare X-linked multisystem disorder presenting with major abnormalities in
the eyes, kidneys, and central nervous system, is caused by mutations in OCRL gene …