Transcription factor 4 and its association with psychiatric disorders
JR Teixeira, RA Szeto, VMA Carvalho… - Translational …, 2021 - nature.com
The human transcription factor 4 gene (TCF4) encodes a helix–loop–helix transcription
factor widely expressed throughout the body and during neural development. Mutations in …
factor widely expressed throughout the body and during neural development. Mutations in …
Neurodevelopmental perspectives on Wnt signaling in psychiatry
KA Mulligan, BNR Cheyette - Complex Psychiatry, 2017 - karger.com
Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse
mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In …
mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In …
A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder
Autism spectrum disorder (ASD) is genetically heterogeneous with convergent
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
symptomatology, suggesting common dysregulated pathways. In this study, we analyzed …
Neurexins cluster Ca2+ channels within the presynaptic active zone
F Luo, A Sclip, M Jiang, TC Südhof - The EMBO journal, 2020 - embopress.org
To achieve ultrafast neurotransmission, neurons assemble synapses with highly organized
presynaptic and postsynaptic nanomachines that are aligned by synaptic adhesion …
presynaptic and postsynaptic nanomachines that are aligned by synaptic adhesion …
The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual …
MP Forrest, MJ Hill, DH Kavanagh… - Schizophrenia …, 2018 - academic.oup.com
Background Common genetic variants in and around the gene encoding transcription factor
4 (TCF4) are associated with an increased risk of schizophrenia. Conversely, rare damaging …
4 (TCF4) are associated with an increased risk of schizophrenia. Conversely, rare damaging …
Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities
The TCF4 gene is the subject of numerous and varied investigations of it's role in the
genesis of neuropsychiatric disease. The gene has been identified as the cause of Pitt …
genesis of neuropsychiatric disease. The gene has been identified as the cause of Pitt …
Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and …
M Jung, BM Häberle, T Tschaikowsky, MT Wittmann… - Molecular autism, 2018 - Springer
Background Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-
Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants …
Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants …
The schizophrenia-and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity …
Disruption of the laminar and columnar organization of the brain is implicated in several
psychiatric disorders. Here, we show in utero gain-of-function of the psychiatric risk gene …
psychiatric disorders. Here, we show in utero gain-of-function of the psychiatric risk gene …
Modulation of cognition and neuronal plasticity in gain-and loss-of-function mouse models of the schizophrenia risk gene Tcf4
The transcription factor TCF4 was confirmed in several large genome-wide association
studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic …
studies as one of the most significant schizophrenia (SZ) susceptibility genes. Transgenic …
The intellectual disability and schizophrenia associated transcription factor TCF4 is regulated by neuronal activity and protein kinase A
Transcription factor 4 (TCF4 also known as ITF2 or E2-2) is a basic helix-loop-helix (bHLH)
protein associated with Pitt–Hopkins syndrome, intellectual disability, and schizophrenia …
protein associated with Pitt–Hopkins syndrome, intellectual disability, and schizophrenia …