BACKGROUND Advanced maternal age is associated with reduced fertility and adverse
pregnancy outcomes. This review details recent developments in our understanding of the …

Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …

The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …

Juvenile hormone (JH) mediates the relationship between fecundity and nutrition during the
gonotrophic cycle of the mosquito in three ways:(1) by regulating initial previtellogenic …

Multiple types of cell death exist including necrosis, apoptosis, and autophagic cell death.
The Drosophila ovary provides a valuable model to study the diversity of cell death …

Even with the benefit of assisted reproductive technologies (ART), many women are unable
to conceive and deliver healthy offspring. One common cause of infertility is the inability to …

We have shown that inhibition of mTOR in granulosa cells and ovarian follicles results in
compromised granulosa proliferation and reduced follicle growth. Further analysis here …

OBJECTIVE: To determine whether oocyte loss is induced by mTOR kinase inhibition in
human cortical strips as seen in model organisms in vivo and in vitro. DESIGN: Ovarian …

Programmed cell death occurs in the germline of many organisms, both as an essential part
of development and throughout adult life. Germline cell death can be apoptotic or …

Advances in cancer therapy have focused attention on the quality of life of cancer survivors.
Since infertility is a major concern following chemotherapy, it is important to characterize the …