Novel systemic inflammation markers to predict COVID-19 prognosis
Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, challenging both
the medical and scientific community for the development of novel vaccines and a greater …
the medical and scientific community for the development of novel vaccines and a greater …
[HTML][HTML] Role of machine learning techniques to tackle the COVID-19 crisis: systematic review
Background: SARS-CoV-2, the novel coronavirus responsible for COVID-19, has caused
havoc worldwide, with patients presenting a spectrum of complications that have pushed …
havoc worldwide, with patients presenting a spectrum of complications that have pushed …
Genetic mechanisms of critical illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
NR Cheemarla, TA Watkins, VT Mihaylova… - Journal of Experimental …, 2021 - rupress.org
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …
infection, and the replication level correlates with the likelihood of viral transmission. Here …
[HTML][HTML] Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs
J Lopez, M Mommert, W Mouton, A Pizzorno… - Journal of Experimental …, 2021 - rupress.org
IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2
infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3 …
infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3 …
Pharmacological activation of STING blocks SARS-CoV-2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic, resulting in millions of infections and deaths with few effective interventions …
pandemic, resulting in millions of infections and deaths with few effective interventions …
[HTML][HTML] Natural mucosal barriers and COVID-19 in children
BACKGROUND Coronavirus disease 2019 (COVID-19) is more benign in children
compared with adults for unknown reasons. This contrasts with other respiratory viruses …
compared with adults for unknown reasons. This contrasts with other respiratory viruses …
[HTML][HTML] Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott… - Cell Reports, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …
The importance and challenges of identifying SARS-CoV-2 reinfections
A Babiker, CE Marvil, JJ Waggoner… - Journal of clinical …, 2021 - Am Soc Microbiol
Reports of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection have
raised important questions about the strength and durability of the immune response to …
raised important questions about the strength and durability of the immune response to …