Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

Background Pronounced anti-inflammatory and anti-apoptotic features have been
characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on ethanol …

Background and purpose: Insulin resistance (IR) and obesity predispose diseases such as
diabetes, cardiovascular and neurodegenerative disorders. Beta-caryophyllene (BCP), a …

Background The frequency of gastrointestinal ulcerations is higher in cirrhotic patients than
in the normal population. It has been shown that pioglitazone exhibits gastroprotective …

Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and
a leading cause of death, with no available cure. We assessed the actions in pulmonary …

Adiponectin and leptin are major adipocytokines that control crosstalk between adipose
tissue and other organ systems. Hypoadiponectinemia and hypoleptinemia are associated …

Abstract Background/Aims Synovial fibrosis is a pathological process that is observed in
several musculoskeletal disorders and characterized by the excessive deposition of …

Objectives: To establish the molecular background for glucocorticoid insensitivity, that is,
failure to reduce edema formation and to protect blood–brain barrier integrity after acute …