Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause
human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

Objective. Ferroptosis, a newly identified form of cell death, plays critical roles in the
development and chemoresistance of lung cancer. Tripartite motif 6 (TRIM6) acts as an E3 …

Abstract Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin
ligases involved in different cellular functions. Of special interest are their roles in innate …

The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …

Summary Type I interferons (IFN-I) are essential to establish antiviral innate immunity.
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …

As an enveloped virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
contains a membrane protein (M) that mediates viral release from cellular membranes …

Ubiquitination of proteins is a post-translational modification process with many different
cellular functions, including protein stability, immune signaling, antiviral functions and virus …