Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

Based on promising preclinical evidence, microglial P2X7 has increasingly being
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Background and Purpose An increasing body of evidence suggests that the purinergic
receptor P2X, ligand‐gated ion channel, 7 (P2X7) in the CNS may play a key role in …

There is a brief summary of the background literature about purinergic signalling. The review
then considers purinergic mechanosensory transduction involved in visceral, cutaneous and …

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in
Alzheimer's disease (AD) in which all proposed treatments investigated in murine models …