The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients
This review aims to provide an extensive overview of the literature on the clinical
pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of …
pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of …
UDP-glucuronosyltransferases and clinical drug-drug interactions
TKL Kiang, MHH Ensom, TKH Chang - Pharmacology & therapeutics, 2005 - Elsevier
UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
S Oda, T Fukami, T Yokoi, M Nakajima - Drug metabolism and …, 2015 - Elsevier
UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping …
JO Miners, PI Mackenzie, KM Knights - Drug metabolism reviews, 2010 - Taylor & Francis
Major advances in the characterization of uridine diphosphate (UDP)-
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …
The role of organic anion–transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics
The goal of this study was to determine the roles of the organic anion–transporting
polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the …
polypeptides (OATPs) OATP1A2, OATP1B1, and OATP1B3 and their genetic variants in the …
Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
Background. Mycophenolic acid (MPA) is glucuronidated by uridine diphosphate-
glucuronosyltransferases (UGTs) to its pharmacologically inactive 7-O-glucuronide …
glucuronosyltransferases (UGTs) to its pharmacologically inactive 7-O-glucuronide …
Transcriptional regulation of human UDP-glucuronosyltransferase genes
Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …
The impact of uridine diphosphate–glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single‐nucleotide polymorphisms T—275A and C—2152T on …
DRJ Kuypers, M Naesens, S Vermeire… - Clinical …, 2005 - Wiley Online Library
Background Mycophenolic acid (MPA), an effective immunosuppressive drug used in renal
transplantation, is extensively glucuronidated by several uridine diphosphate …
transplantation, is extensively glucuronidated by several uridine diphosphate …