Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Mitochondrial division is not an autonomous event but involves multiple organelles,
including the endoplasmic reticulum (ER) and lysosomes. Whereas the ER drives the …

Cardiovascular diseases are one of the leading causes of death. Increasing evidence has
shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage …

Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps
best known as a master regulator of mitochondrial biogenesis and function. However, by …

Astrocytes, often considered as secondary responders to neurodegeneration, are emerging
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …

Mitochondria-related neurodegenerative diseases have been implicated in the disruption of
primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

Macroautophagy/autophagy is a self-degradative process necessary for cells to maintain
their energy balance during development and in response to nutrient deprivation …

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized
by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix …