Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Free radicals induced oxidative stress at a molecular level: The current status, challenges and perspectives of computational chemistry based protocols

A Galano - Journal of the Mexican Chemical Society, 2015 - scielo.org.mx
Oxidative stress is frequently caused by an excess of free radicals and has been associated
with a wide variety of health disorders. Therefore, finding strategies for scavenging free …

Proton-coupled electron transfer in DNA on formation of radiation-produced ion radicals

A Kumar, MD Sevilla - Chemical reviews, 2010 - ACS Publications
It is well established that exposure of DNA to high-energy radiation results in a variety of
physical and chemical changes in DNA including strand breakage, mutation, and DNA …

Charged particle and photon interactions with matter: recent advances, applications, and interfaces

Y Hatano, Y Katsumura, A Mozumder - 2010 - books.google.com
Covering state-of-the-art advances, novel applications, and future perspectives, this volume
presents new directions on the basic studies of charged particle and photon interactions with …

The guanine cation radical: Investigation of deprotonation states by ESR and DFT

A Adhikary, A Kumar, D Becker… - The Journal of Physical …, 2006 - ACS Publications
This work reports ESR studies that identify the favored site of deprotonation of the guanine
cation radical (G•+) in an aqueous medium at 77 K. Using ESR and UV− visible …

On the chemical repair of DNA radicals by glutathione: hydrogen vs electron transfer

JR Alvarez-Idaboy, A Galano - The Journal of Physical Chemistry …, 2012 - ACS Publications
The chemical repair of radical-damaged DNA by glutathione in aqueous solution has been
studied using density functional theory. Two main mechanisms were investigated: the single …

Uv–vis action spectroscopy of guanine, 9-methylguanine, and guanosine cation radicals in the gas phase

A Dang, Y Liu, F Tureček - The Journal of Physical Chemistry A, 2019 - ACS Publications
Cation radicals of guanine (G•+), 9-methylguanine (MG•+), and guanosine (rG•+) were
generated by dissociative oxidation of gas-phase copper complexes and characterized by …

UVA-visible photo-excitation of guanine radical cations produces sugar radicals in DNA and model structures

A Adhikary, AYS Malkhasian, S Collins… - Nucleic acids …, 2005 - academic.oup.com
This work presents evidence that photo-excitation of guanine radical cations results in high
yields of deoxyribose sugar radicals in DNA, guanine deoxyribonucleosides and …

Electron spin resonance of radicals in irradiated DNA

A Adhikary, D Becker, MD Sevilla - Applications of EPR in radiation …, 2014 - Springer
Ionizing radiation produces DNA-cation radical (hole) and DNA-anion radical formation by
random direct ionization of DNA and its microenvironments (eg, layer of hydration) as well …