Systems medicine: the future of medical genomics and healthcare

C Auffray, Z Chen, L Hood - Genome medicine, 2009 - Springer
High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

A comprehensive overview and critical evaluation of gene regulatory network inference technologies

M Zhao, W He, J Tang, Q Zou… - Briefings in bioinformatics, 2021 - academic.oup.com
Gene regulatory network (GRN) is the important mechanism of maintaining life process,
controlling biochemical reaction and regulating compound level, which plays an important …

Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics

L Wang, N Trasanidis, T Wu, G Dong, M Hu… - Nature …, 2023 - nature.com
Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during environmental turmoil

M Ebadi, Q Bafort, E Mizrachi… - Proceedings of the …, 2023 - National Acad Sciences
The importance of whole-genome duplication (WGD) for evolution is controversial. Whereas
some view WGD mainly as detrimental and an evolutionary dead end, there is growing …

Consistency of community detection in networks under degree-corrected stochastic block models

Y Zhao, E Levina, J Zhu - 2012 - projecteuclid.org
Consistency of community detection in networks under degree-corrected stochastic block
models Page 1 The Annals of Statistics 2012, Vol. 40, No. 4, 2266–2292 DOI: 10.1214/12-AOS1036 …

Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis

S Chandrasekaran, ND Price - Proceedings of the National …, 2010 - National Acad Sciences
Prediction of metabolic changes that result from genetic or environmental perturbations has
several important applications, including diagnosing metabolic disorders and discovering …

AGRIS: the Arabidopsis gene regulatory information server, an update

A Yilmaz, MK Mejia-Guerra, K Kurz, X Liang… - Nucleic acids …, 2010 - academic.oup.com
Abstract The Arabidopsis Gene Regulatory Information Server (AGRIS; http://arabidopsis.
med. ohio-state. edu/) provides a comprehensive resource for gene regulatory studies in the …

Hive plots—rational approach to visualizing networks

M Krzywinski, I Birol, SJM Jones… - Briefings in …, 2012 - academic.oup.com
Networks are typically visualized with force-based or spectral layouts. These algorithms lack
reproducibility and perceptual uniformity because they do not use a node coordinate system …

Learning in transcriptional network models: computational discovery of pathway-level memory and effective interventions

S Biswas, W Clawson, M Levin - International Journal of Molecular …, 2022 - mdpi.com
Trainability, in any substrate, refers to the ability to change future behavior based on past
experiences. An understanding of such capacity within biological cells and tissues would …

Supervised learning with decision tree-based methods in computational and systems biology

P Geurts, A Irrthum, L Wehenkel - Molecular Biosystems, 2009 - pubs.rsc.org
At the intersection between artificial intelligence and statistics, supervised learning allows
algorithms to automatically build predictive models from just observations of a system …