Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic
ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with …

Significance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus
causing coronavirus disease 2019 (COVID-19), affects every aspect of human life by …

Mitochondria are key structures providing most of the energy needed to maintain
homeostasis. They are the main source of adenosine triphosphate (ATP), participate in …

Background Serum sulfhydryl groups (R-SH, free thiols) reliably reflect the systemic redox
status in health and disease. As oxidation of R-SH occurs rapidly by reactive oxygen species …

Living organisms need to be able to cope with environmental challenges and other stressors
and mount adequate responses that are as varied as the spectrum of those challenges …

Abstract In septic mice, 3-hydroxybutyrate-sodium-salt has shown to partially prevent sepsis-
induced muscle weakness. Although effective, the excessive sodium load was toxic. We …

Background Fatty acid oxidation (FAO) defects have been implicated in experimental
models of acute lung injury and associated with poor outcomes in critical illness. In this …

Argininosuccinate lyase (ASL) is a key enzyme integral to the hepatic urea cycle which is
required for ammonia detoxification, and the citrulline-nitric oxide (NO) cycle for NO …