Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular
mechanisms involved in the regulation of conventional outflow resistance and thus …

With the combined purpose of facilitating useful vision over a lifetime, a number of ocular
cells have evolved specialized features not found elsewhere in the body. The trabecular …

purpose. Transforming growth factor (TGF)-β2 levels are elevated in glaucomatous human
aqueous humor. TGFβ is a cytokine that alters extracellular matrix (ECM) metabolism, and …

Exosomes are extracellular nanovesicles that mediate a number of cellular processes,
including intracellular signalling. There are many published examples of exosome …

Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …

Purpose To investigate the role of miR-29b on the changes in expression of genes involved
in the synthesis and deposition of extracellular matrix (ECM) induced by chronic oxidative …

Glaucoma is a heterogeneous group of optic neuropathies that manifests by optic nerve
head cupping or degeneration of the optic nerve, resulting in a specific pattern of visual field …

Glaucoma is a common cause of vision loss or blindness and reduction of intraocular
pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP …

purpose. To examine the intracellular and extracellular expression of myocilin in the human
and primate trabecular meshwork (TM) in the presence and absence of glucocorticoids …

purpose. Trabecular meshwork (TM) cells appear to sense changes in intraocular pressure
(IOP) as mechanical stretching. In response, they make homeostatic corrections in the …