Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

B Zeng, A Wei, Q Zhou, M Yuan, K Lei… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in
China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and …

Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies

M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …

[HTML][HTML] Medicinal plants: adjunct treatment to tuberculosis chemotherapy to prevent hepatic damage

N Mangwani, PK Singh, V Kumar - Journal of Ayurveda and integrative …, 2020 - Elsevier
The effectiveness of herbs for the management of chemically induced hepatotoxicity has
been discussed by many researchers. However, there is a paucity of compressive literature …

Herb‐drug interactions in diabetes mellitus: A review based on pre‐clinical and clinical data

AK Thikekar, AB Thomas… - Phytotherapy …, 2021 - Wiley Online Library
Global diabetes epidemic is the major cause of fatality and lethality. As per IDF 2019 report,
diabetes caused 4.2 million deaths, approximately 463 million people are living with …

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

HW Chen, CS Huang, CC Li, AH Lin, YJ Huang… - Toxicology and applied …, 2014 - Elsevier
Andrographolide, a bioactive diterpenoid, is identified in Andrographis paniculata. In this
study, we investigated the pharmacokinetics and bioavailability of andrographolide in rats …

Andrographolide, a new hope in the prevention and treatment of metabolic syndrome

MT Islam - Frontiers in pharmacology, 2017 - frontiersin.org
Recently, the use of plant-derived medicines is increasing interest in the prevention and
treatment of a variety of disorders including metabolic syndromes. Metabolic syndrome is …

Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata

N Zhu, J Hou, N Yang - Scientific Reports, 2021 - nature.com
Inflammation is a key factor in the development and complications of various diseases
because it has a complex pathogenesis. Andrographis paniculate (Burm. f.) Nees (Chuan …

The role of Andrographolide in the prevention and treatment of liver diseases

X Qin, X Wang, M Tian, Z Dong, J Wang, C Wang… - Phytomedicine, 2023 - Elsevier
Background The presence or absence of damage to the liver organ is crucial to a person's
health. Nutritional disorders, alcohol consumption, and drug abuse are the main causes of …

Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC …

E Sundhani, AE Nugroho, A Nurrochmad, I Puspitasari… - Molecules, 2022 - mdpi.com
Co-administered medicinal herbs can modify a drug's pharmacokinetics (PK), effectiveness,
and toxicity. Andrographis paniculata (Burm. f.) ethanolic extract (APE) and andrographolide …

Herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide on pharmacokinetic and pharmacodynamic of naproxen in rats

A Balap, S Lohidasan, A Sinnathambi… - Journal of …, 2017 - Elsevier
Abstract Ethnopharmacological relevance Andrographis paniculata Nees (Acanthacae)
have broad range of pharmacological effects such as hepatoprotective, antifertility …