[HTML][HTML] Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease

SP Yu, MQ Jiang, SS Shim, S Pourkhodadad… - Molecular …, 2023 - Springer
Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

[HTML][HTML] TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implications

Z Gu, H Cao, C Zuo, Y Huang, J Miao, Y Song… - Neurobiology of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
most prevalent neurodegenerative disease worldwide. The primary pathological hallmarks …

[HTML][HTML] Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk

MM Aslam, KH Fan, E Lawrence, MA Bedison… - Molecular …, 2023 - nature.com
Abstract The APOE 2/3/4 polymorphism is the greatest genetic risk factor for Alzheimer's
disease (AD). This polymorphism is also associated with variation in plasma ApoE level; …

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort

PCL Ferreira, Y Zhang, B Snitz… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's
disease (AD) and related disorders (ADRD)—have largely been studied in clinical research …

Menopausal vasomotor symptoms and white matter hyperintensities in midlife women

RC Thurston, M Wu, YF Chang, HJ Aizenstein… - Neurology, 2023 - AAN Enterprises
Background and Objectives The menopause transition is increasingly recognized as a time
of importance for women's brain health. A growing body of work indicates that the classic …

[HTML][HTML] Regulation of the hippocampal translatome by Apoer2-ICD release

CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …

Posttraumatic stress disorder symptoms and cardiovascular and brain health in women

RC Thurston, K Jakubowski, Y Chang, M Wu… - JAMA Network …, 2023 - jamanetwork.com
Importance Posttraumatic stress disorder (PTSD), cardiovascular disease (CVD), and
Alzheimer disease are major public health issues, particularly for women. The implications …

[HTML][HTML] Alzheimer's disease seen through the eye: ocular alterations and neurodegeneration

D Romaus-Sanjurjo, U Regueiro… - International Journal of …, 2022 - mdpi.com
Alzheimer's Disease (AD) is one of the main neurodegenerative diseases worldwide.
Unfortunately, AD shares many similarities with other dementias at early stages, which …

[HTML][HTML] Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence

A Azargoonjahromi, F Abutalebian - Nutrition & Metabolism, 2024 - Springer
Context Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has
been extensively studied for its potential in treating Alzheimer's disease (AD). RV has shown …

Using Drosophila to identify naturally occurring genetic modifiers of amyloid beta 42- and tau-induced toxicity

M Yang, M Zinkgraf, C Fitzgerald-Cook… - G3: Genes …, 2023 - academic.oup.com
Alzheimer's disease is characterized by 2 pathological proteins, amyloid beta 42 and tau.
The majority of Alzheimer's disease cases in the population are sporadic and late-onset …