Abstract Hugo Schiff (1864), was the first who synthesized Schiff bases by the condensation
reaction of primary amines with carbonyl compounds (aldehyde or ketone). Schiff bases …

Thiourea and its derivatives display several electronic and structural features which enable
its application in various fields, ranging from biological to non-biological. These compounds …

Access to efficient enzymatic channeling is desired for improving all manner of designer
biocatalysis. We demonstrate that enzymes constituting a multistep cascade can self …

In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …

The last big outbreaks of Ebola fever in Africa, the thousands of avian influenza outbreaks
across Europe, Asia, North America and Africa, the emergence of monkeypox virus in …

The immunomodulatory effect of divalent manganese cations (Mn2+), such as activation of
the cGAS− STING pathway or NLRP3 inflammasomes, positions them as adjuvants for …

Drug delivery via nanovehicles is successfully employed in several clinical settings, yet
bacterial infections, forming microbial communities in the form of biofilms, present a strong …

Hexahistidine-tagged proteins can be clustered by divalent cations into self-containing,
dynamic protein depots at the microscale, which under physiological conditions leak …

Among bio-inspired protein materials, secretory protein microparticles are of clinical interest
as self-contained, slow protein delivery platforms that mimic secretory granules of the human …

Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and
diagnostic agents has garnered increased interest. Several nanoparticle drug delivery …