Autonomic cardiovascular control is impaired in hypertension, leading to a reduction in the
parasympathetic tone and to an increase in the sympathetic influences to the heart and …

α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in
neurotransmission and regulate the sympathetic nervous system through binding and …

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha 1-ARs signal through Gα q, and signaling …

Cardiac myocytes are activated by hormonal and mechanical signals and respond in a
variety of ways, from altering contractile function to inducing cardio-protection and growth …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac
adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the …

Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and
nervous systems where they regulate blood pressure, cognition, and metabolism. However …

The adrenergic system is an essential regulator of neuronal, endocrine, cardiovascular,
vegetative, and metabolic functions. The endogenous catecholamines epinephrine and …

In this review, subtypes of functional α1-adrenoceptor are discussed. These are cell
membrane receptors, belonging to the seven-transmembrane-spanning G-protein-linked …

The noradrenergic and cholinergic modulation of functionally distinct regions of the brain
has become one of the primary organizational principles behind understanding the …