Design of prospective antiparasitic metal-based compounds including selected organometallic cores

D Gambino, L Otero - Inorganica Chimica Acta, 2018 - Elsevier
A group of seventeen communicable and poverty-related diseases are considered
neglected by the World Health Organization due to the restricted development of diagnostic …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, RMS Justo, GYS Delgado… - Current …, 2021 - benthamdirect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

Novel tetranuclear Pd II and Pt II anticancer complexes derived from pyrene thiosemicarbazones

CG Oliveira, I Romero-Canelón, JPC Coverdale… - Dalton …, 2020 - pubs.rsc.org
Cyclometallated palladium (II) and platinum (II) pyrenyl-derived thiosemicarbazone (H2PrR)
complexes of the type [M4 (μ-S-PrR-κ3-C, N, S) 4](M= PdII, PtII; R= ethyl, cyclohexyl) have …

Cyclometalated Gold (III) complexes bearing DACH ligands

S Gukathasan, S Parkin, SG Awuah - Inorganic chemistry, 2019 - ACS Publications
The synthesis of a novel class of cyclometalated gold (III) complexes supported by
benzoylpyridine, benzylpyridine, and (1 R, 2 R)-(+)-1, 2-diaminocyclohexane (DACH) …

Exploring antiviral and antiparasitic activity of gold N-heterocyclic carbenes with thiolate ligands

IS Oliveira, MSA Garcia, NM Cassani… - Dalton …, 2024 - pubs.rsc.org
Gold (I) N-heterocyclic carbenes have been explored for their therapeutic potential against
several diseases. Neglected tropical diseases, including leishmaniasis, Chagas disease …

PtII, PdII and AuIII complexes with a thiosemicarbazone derived from diacethylmonooxime: Structural analysis, trypanocidal activity, cytotoxicity and first insight into the …

ACR Goncalves, ZA Carneiro, CG Oliveira… - European Journal of …, 2017 - Elsevier
New complexes of composition [MX (HL1)](M= Pt II, Pd II, X= Cl− or I−) and [MX (L1)](M= Au
III, X= Cl−; M= Pt II, Pd II, X= PPh 3) have been synthesized using a potentially tridentate …

Characterization of the activities of dinuclear thiolato-bridged arene ruthenium complexes against Toxoplasma gondii

AP Basto, J Müller, R Rubbiani, D Stibal… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The in vitro effects of 18 dinuclear thiolato-bridged arene ruthenium complexes (1
monohiolato compound, 4 dithiolato compounds, and 13 trithiolato compounds), originally …

Heterobimetallic nickel (II) and palladium (II) complexes derived from S-benzyl-N-(ferrocenyl) methylenedithiocarbazate: Trypanocidal activity and interaction with …

ZA Carneiro, JC Lima, CD Lopes, APS Gaspari… - European Journal of …, 2019 - Elsevier
Reactions of Ni (II) and Pd (II) precursors with S-benzyl-N-(ferrocenyl)
methylenedithiocarbazate (HFedtc) led to the formation of heterobimetallic complexes of the …

[HTML][HTML] Potential of sulfur-selenium isosteric replacement as a strategy for the development of new anti-chagasic drugs

M Rubio-Hernández, V Alcolea, S Pérez-Silanes - Acta Tropica, 2022 - Elsevier
Current treatment for Chagas disease is based on only two drugs: benznidazole and
nifurtimox. Compounds containing sulfur (S) in their structure have shown promising results …

Exploring Synthetic Dihydrobenzofuran and Benzofuran Neolignans as Antiprotozoal Agents against Trypanosoma cruzi

MC Pagotti, HJ Dias, ACBB Candido, TAS Oliveira… - Pharmaceutics, 2023 - mdpi.com
Chagas disease is a neglected tropical disease that affects more than 8 million people.
Although there are therapies against this disease, the search for new drugs is important …