Molecular pathways underlying cholesterol homeostasis

MS Afonso, RM Machado, MS Lavrador, ECR Quintao… - Nutrients, 2018 - mdpi.com
Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …

ZnO for performance enhancement of surface plasmon resonance biosensor: a review

GS Mei, PS Menon, G Hegde - Materials Research Express, 2020 - iopscience.iop.org
This paper reviews Kretschmann-based SPR sensor utilizing ZnO thin films and
nanostructures for performance enhancement. The advancement in surface plasmon …

Properties and biotechnological applications of acyl‐CoA: diacylglycerol acyltransferase and phospholipid: diacylglycerol acyltransferase from terrestrial plants and …

Y Xu, KMP Caldo, D Pal‐Nath, J Ozga, MJ Lemieux… - Lipids, 2018 - Wiley Online Library
Triacylglycerol (TAG) is the major storage lipid in most terrestrial plants and microalgae, and
has great nutritional and industrial value. Since the demand for vegetable oil is consistently …

Deciphering structural aspects of reverse cholesterol transport: mapping the knowns and unknowns

S Sacher, A Mukherjee, A Ray - Biological Reviews, 2023 - Wiley Online Library
Atherosclerosis is a major contributor to the onset and progression of cardiovascular
disease (CVD). Cholesterol‐loaded foam cells play a pivotal role in forming atherosclerotic …

High-density lipoproteins: a role in inflammation in COPD

S Kotlyarov - International Journal of Molecular Sciences, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a widespread disease associated with
high rates of disability and mortality. COPD is characterized by chronic inflammation in the …

Molecular basis for activation of lecithin: cholesterol acyltransferase by a compound that increases HDL cholesterol

KA Manthei, SM Yang, B Baljinnyam, L Chang… - Elife, 2018 - elifesciences.org
Lecithin: cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being
investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency …

Rescue of familial lecithin: cholesterol Acyltranferase Deficiency mutations with an Allosteric activator

KA Manthei, GE Tremonti, L Chang, A Niemelä… - Molecular …, 2024 - Elsevier
Lecithin: cholesterol acyltransferase (LCAT) deficiencies represent severe disorders
characterized by aberrant cholesterol esterification in plasma, leading to life-threatening …

Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein AI Mimetic Peptides and …

L Giorgi, A Niemela, EP Kumpula, O Natri… - Molecular …, 2022 - ACS Publications
The mechanistic details behind the activation of lecithin–cholesterol acyltransferase (LCAT)
by apolipoprotein AI (apoA-I) and its mimetic peptides are still enigmatic. Resolving the …

Structural analysis of lecithin: cholesterol acyltransferase bound to high density lipoprotein particles

KA Manthei, D Patra, CJ Wilson, MV Fawaz… - Communications …, 2020 - nature.com
Lecithin: cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol
transport by esterifying cholesterol in high density lipoprotein (HDL) particles. LCAT is …

Systematic evaluation of lecithin: Cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: Regulatory role of charged residues at …

A Niemelä, A Koivuniemi - PLOS Computational Biology, 2024 - journals.plos.org
Lecithin: cholesterol acyltransferase (LCAT) exhibits α-activity on high-density and β-activity
on low-density lipoproteins. However, the molecular determinants governing LCAT …