The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …

The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule
regulating interactions between cells and their surrounding extracellular matrix (ECM). This …

Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …

Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …

Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases
affecting millions worldwide. Both diseases have links to cigarette smoking and exert a …

Introduction: COPD and lung cancer are leading causes of morbidity and mortality
worldwide, and they share a common environmental risk factor in cigarette smoke exposure …

Remodeling of the extracellular matrix (ECM) is a common feature in lung diseases such as
chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) …

Type 2 diabetes mellitus (T2DM) is a widespread metabolic condition with a high global
morbidity and mortality rate that affects the whole body. Their primary consequences are …

Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is
associated with disease severity in patients with chronic obstructive pulmonary disease …

Globally, chronic respiratory diseases (CRDs), both communicable and noncommunicable,
are among the leading causes of mortality, morbidity, economic and societal burden, and …