Flavonoids: classification, function, and molecular mechanisms involved in bone remodelling

P Ramesh, R Jagadeesan, S Sekaran… - Frontiers in …, 2021 - frontiersin.org
Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea
plants, and stems and many more natural commodities. They have a multitude of …

Antimicrobial peptide-based materials: Opportunities and challenges

A Rai, R Ferrão, P Palma, T Patricio… - Journal of Materials …, 2022 - pubs.rsc.org
The multifunctional properties of antimicrobial peptides (AMPs) make them attractive
candidates for the treatment of various diseases. AMPs are considered as alternatives to …

Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

J An, H Yang, Q Zhang, C Liu, J Zhao, L Zhang, B Chen - Life sciences, 2016 - Elsevier
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …

The genus Epimedium: an ethnopharmacological and phytochemical review

H Ma, X He, Y Yang, M Li, D Hao, Z Jia - Journal of ethnopharmacology, 2011 - Elsevier
Epimedium (Berberidaceae), is a genus of about 52 species in the family Berberidaceae,
which also known as Rowdy Lamb Herb, Xianlinpi, Barrenwort, Bishop's Hat, Fairy Wings …

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

C Li, Q Li, Q Mei, T Lu - Life Sciences, 2015 - Elsevier
Herba Epimedii is an important medicinal plant which has been used in various traditional
Chinese formulations for thousands of years as well as in modern proprietary traditional …

Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

J He, X Li, Z Wang, S Bennett, K Chen, Z Xiao… - Frontiers in …, 2019 - frontiersin.org
Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture
due to the reduced bone mass and microstructural degradation. Primary pharmacological …

[PDF][PDF] Pharmacological agents and natural compounds: available treatments for osteoporosis.

M Martiniakova, M Babikova, R Omelka - Journal of Physiology & …, 2020 - jpp.krakow.pl
Osteoporosis, a systemic skeletal disease characterized by a decrease in bone mass and
deterioration of bone structure leading to an increased risk of fragility fractures, represents …

Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

LG Ming, KM Chen, CJ Xian - Journal of cellular physiology, 2013 - Wiley Online Library
Increasingly natural products particularly flavonoids are being explored for their therapeutic
potentials in reducing bone loss and maintaining bone health. This study has reviewed …

Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

L Song, J Zhao, X Zhang, H Li, Y Zhou - European journal of pharmacology, 2013 - Elsevier
Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an
anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats …

Local drug delivery for enhancing fracture healing in osteoporotic bone

L Kyllönen, M D'Este, M Alini, D Eglin - Acta biomaterialia, 2015 - Elsevier
Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …