Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Global reporting of 5 million more malaria cases in 2016 comparative to 211 million cases
reported in 2015 makes malaria overwhelming parasitic disease caused by Plasmodium …

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative condition
distinguished by the deposition of amyloid beta plaques and neurofibrillary tangles in the …

Due to the low structural diversity within the set of antimalarial drugs currently available in
the clinic and the increasing number of cases of resistance, there is an urgent need to find …

The present study aimed to enhance the efficacy of Curcumin (CR) by a nanophytosomal
based drug delivery system. The DSPE-PEG-CSA lipid-polymer was synthesized and its …

In the field of medicinal chemistry, the concept of pharmacophore refers to the specific
region of a molecule that possesses essential structural and chemical characteristics for …

An integrated virtual screening protocol by combining molecular docking and
pharmacophore mapping was established to identify novel inhibitors of JAK2 from a …

Ethnopharmacological relevance Malaria, a devastating infectious disease which was
initially recognized as episodic fever, is caused by parasitic protozoan of the genus …

The aim of this study was to evaluate the antifungal and cytotoxic activities of the oxidized
form of amphotericin B (AmB-Ox) as well as to determine whether oxidation process of AmB …

CC chemokine receptor 5 (CCR5), a member of G protein-coupled receptors (GPCRs), not
only plays a significant role in inflammatory responses, but also correlates with HIV-1 …