Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … Reviews Molecular Cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

When anaerobes encounter oxygen: mechanisms of oxygen toxicity, tolerance and defence

Z Lu, JA Imlay - Nature reviews microbiology, 2021 - nature.com
The defining trait of obligate anaerobes is that oxygen blocks their growth, yet the underlying
mechanisms are unclear. A popular hypothesis was that these microorganisms failed to …

[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis

H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

The role of thiols in antioxidant systems

K Ulrich, U Jakob - Free Radical Biology and Medicine, 2019 - Elsevier
The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Full-coverage regulations of autophagy by ROS: from induction to maturation

J Zhou, XY Li, YJ Liu, J Feng, Y Wu, HM Shen, GD Lu - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily well-conserved recycling process in
response to stress conditions, including a burst of reactive oxygen species (ROS) …

[HTML][HTML] Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

H Sies - Redox biology, 2017 - Elsevier
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …

[HTML][HTML] Physiological signaling functions of reactive oxygen species in stem cells: From flies to man

SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

The significance of mitochondrial dysfunction in cancer

Y Luo, J Ma, W Lu - International journal of molecular sciences, 2020 - mdpi.com
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …