Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …

Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the
transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK …

An ability to separate natural ageing processes from processes specific to morbidities is
required to understand the heterogeneity of age-related organ dysfunction. Mechanistic …

Since the sequence of the human genome is complete, the main issue is how to understand
the information written in the DNA sequence. Despite numerous genome-wide studies that …

An increasing number of studies have shown that immune inflammatory response plays a
vital role in diabetic kidney disease (DKD). Nod-like receptor protein 3 (NLRP3) …

Background Diabetic nephropathy is the single strongest predictor of mortality in patients
with diabetes. The development of overt nephropathy involves important inter-individual …

The growing epidemic of obesity and diabetes, the aging population as well as prevalence
of drug abuse has led to significant increases in the rates of the closely associated acute …

The cells in a human body have identical DNA sequences, yet the body has> 200 cell types
with different phenotypes. The basis for this nongenetic cellular memory, which records …

Only a few percent of the 3 billion pairs of chemical letters in the human genome is
responsible for protein-coding sequences. Recent advances in the field of epigenomics …

Chronic kidney disease (CKD) is a global epidemic, and its major risk factors include obesity
and type 2 diabetes. Obesity not only promotes metabolic dysregulation and the …